Which type of neuropathy can cause pain or loss of feeling in the toes, feet, and legs?

The type of neuropathy that can cause pain or loss of feeling in the toes, feet, and legs is peripheral neuropathy. This condition specifically affects the peripheral nerves, which are the nerves outside the brain and spinal cord that connect the central nervous system to limbs and organs. When these nerves are damaged or diseased, it can lead to symptoms including pain, tingling, and loss of sensation primarily in the extremities, such as the toes and feet.

Peripheral neuropathy is often associated with conditions like diabetes, where high blood sugar levels can damage nerves over time. The symptoms can vary widely among individuals, but the characteristic involvement of the legs and feet makes it the most relevant type of neuropathy for this question. Other types of neuropathies mentioned do not typically present with these specific symptoms in the lower extremities. For instance, proximal neuropathy usually affects the hips and thighs and is associated with weakness, while focal neuropathy can affect a specific nerve or group of nerves, causing localized symptoms. Autonomic neuropathy impacts involuntary body functions, which does not primarily include pain or sensation in the extremities.